I took a fair amount of the stuff back in the 1980s -- at one point I estimated my cumulative total consumption as around 15 grams. (I'm sure there are people far beyond that now.)
It is definitely neurotoxic -- I could tell that the first time I took it -- but in my experience, the noticeable effects are temporary, being mostly gone in a couple of weeks and quite undetectable after a couple of months. As a software developer who works in a fairly technical field, I'm quite sensitive to how well my brain is working on any given day. I did not notice any long-term falloff in my abilities as a result of MDMA use.
All that said -- it does invite abuse, and I was abusing it. In 1990, my then-SO left me, and I realized I had to quit.
I wouldn't worry about occasional, supervised, therapeutic MDMA use by healthy individuals.
Same experience here. I took 0.1g to close to 1g on several occasions over a couple years.
Doses in the 0.1-0.2g range would leave me fairly slow the next day, but that's it. With heavier doses I'd see after-effects for about a week (like reaching for my phone and pulling a lighter from my pocket, disconnecting in the middle of a conversation, losing track of time)
The only time it took a long time to fully recover (5-6 weeks, progressively) was after taking some twice in 2 consecutive days. Quantities weren't big, maybe 0.5g total, but the effects lasted really long.
It is definitely neurotoxic -- I could tell that the first time I took it -- but in my experience, the noticeable effects are temporary, being mostly gone in a couple of weeks and quite undetectable after a couple of months. As a software developer who works in a fairly technical field, I'm quite sensitive to how well my brain is working on any given day. I did not notice any long-term falloff in my abilities as a result of MDMA use.
All that said -- it does invite abuse, and I was abusing it. In 1990, my then-SO left me, and I realized I had to quit.
I wouldn't worry about occasional, supervised, therapeutic MDMA use by healthy individuals.