And supposedly half the population that lives West of the Mississippi lives within 30 miles of I-5. Don't have the US Census loaded currently so I can't check it, but that does sound about right.
Given that half the population of the US is 156 million, and half that is 78, it's plausible, but a quick add-up of combined MSAs comes up short:
LA is 18.1 million, San Diego 3.2 Sacramento 2.2, Stockton 0.7, Portland 0.5, and Seattle-Tacoma 3.6. I get about 23.3 million total, which is still 54 million short.
SF-SJ-Oak adds another 8.4 million, but most of it is more than 30 miles from I5.
Checking by state confirms it:
CA: 38m, OR: 3.9m, WA: 6.9m. combined total: 48.8m. Still 30 million short.
Actually, west of the mississippi (and assuming all of Louisiana and Minnesota) the population is only about 130 million - so those three states are about 40% of that population. Given the rapid growth of texas, colorado and arizona, and Nevada (well Las Vegas) in the last 15 years, it wouldn't surprise me if those three states would have been over half the population west of the Mississippi not that long ago.
As for within 5 Miles of I-5.. probably not, but within it's area of influence, for sure - the western parts of those three states are pretty empty, even by my midwest trained standards.