Some of the Linux GUIs used to have a feature that, if you set the mouse to left-handed, the cursor would tilt the other way. It was very ergonomic and seemed natural (and I would like it back :)
FWIW on KDE there are several cursor sets available via the "download new content" system with left-handed primary cursors; but yes it seems you have to select them yourself rather than them being automatically applied.
Most older computers had at least some utility to do this too. I used it a lot on my Atari ST's since I was having troubles with my right hand and had to switch left/right quite a lot.
