Valencia. Taxes are outrageous, for sure. But all other cost of living is much cheaper. And my daughter will most likely go to a European university so when that cost savings is considered, it's a huge net gain regardless of the taxes. My wife and I both work remotely for U.S. organizations. Earning a U.S. salary with Spanish cost of living allows us to have a quality of life far beyond what we had in the U.S.
So basically it’s move to Spain but work remotely for US. I think it’s worth mentioning that part upfront because working remotely for US changes the entire equation of the move.
It possible to work in Spain and be fine. But finding a job in Spain would be challenging (especially if you're not fluent in Spanish) and the average salary is much lower than the U.S. (but so is cost of living). So, it's possible but not nearly as easy.