Works out of the box for me since moving to Fedora running Wayland and Gnome.
I just set one monitor to 100% and the other (4k) to 200%. In fact I think that choice was originally made for me but you can change it.
When I first started using it a couple of years ago you'd get old artifacts when moving a window from one monitor to another. e.g. the mouse pointer could be the wrong size.
Over the years, like many things on Linux, it's got more polished.
I just set one monitor to 100% and the other (4k) to 200%. In fact I think that choice was originally made for me but you can change it.
When I first started using it a couple of years ago you'd get old artifacts when moving a window from one monitor to another. e.g. the mouse pointer could be the wrong size.
Over the years, like many things on Linux, it's got more polished.
Now it just works.