Does it work out of the box or do you need to do something specific. I have a custom built desktop with a 4k and a 1080p monitor. I can get one of them to look good. :( I’m on mint.
Works out of the box for me since moving to Fedora running Wayland and Gnome.
I just set one monitor to 100% and the other (4k) to 200%. In fact I think that choice was originally made for me but you can change it.
When I first started using it a couple of years ago you'd get old artifacts when moving a window from one monitor to another. e.g. the mouse pointer could be the wrong size.
Over the years, like many things on Linux, it's got more polished.