I used to be able to handle really hot peppers up in till college and then one day during college completely over did it .
I'm not sure if that "day" was the cause of my increased sensitivity or if I just age related but now I can barely enjoy red pepper flakes. Oh it goes down just fine but later... later I'm writhing in pain rolling around in the bed at night ... and then later on the toilet ... well I think you know what happens next.
As I get older it seems to get worse which seems like it shouldn't. Shouldn't the receptors be more tolerant? Or maybe it is more like allergens where there is a certain threshold and then once that threshold is exceed you become more and more sensitive (e.g. poison ivy does this).
BTW capsaicin does have a theoretical LD 50 based on mice. So yeah if you eat enough it will probably kill you but it is an outrageous amount (~ 50-100mg/kg). You would have to have it extracted to do it (some one actually went ahead and did the math here on how many peppers: http://skeptics.stackexchange.com/questions/6810/can-you-die...).
I had a similar experience. I grew up eating spicy food, with no issues whatsoever, aside from the topside burn. At 21 I experienced a tipping point wherein my gut became sensitive to spicy foods. I had to rethink my relationship with spicy food, else cope with the symptoms you describe.
I am very curious what the physiological basis for this change is.
Not sure if this is related, but I developed a condition called 'Lichen Planus' in my mouth a couple of years ago, and now it hurts considerably when I eat even the slightest amount of chilli. Sour foods also hurt, but they're easier to wash away. Quite a shame as I used to enjoy a bit of heat.
I'm not sure if that "day" was the cause of my increased sensitivity or if I just age related but now I can barely enjoy red pepper flakes. Oh it goes down just fine but later... later I'm writhing in pain rolling around in the bed at night ... and then later on the toilet ... well I think you know what happens next.
As I get older it seems to get worse which seems like it shouldn't. Shouldn't the receptors be more tolerant? Or maybe it is more like allergens where there is a certain threshold and then once that threshold is exceed you become more and more sensitive (e.g. poison ivy does this).
BTW capsaicin does have a theoretical LD 50 based on mice. So yeah if you eat enough it will probably kill you but it is an outrageous amount (~ 50-100mg/kg). You would have to have it extracted to do it (some one actually went ahead and did the math here on how many peppers: http://skeptics.stackexchange.com/questions/6810/can-you-die...).