Looking at the anecdotes being shared here, I see widely varying accounts of effects/efficacy. I wonder how many actually used 100% MDMA as opposed to one of its more 'designer' variants (blends, analogues, etc) generally available via illicit channels.
There are many analogs being passed off as MDMA. However, it's normal that a given drug won't affect everyone in the same way.
I've had pure MDMA several times (tested). I've supplemented with 5-HTP and antioxidants, made sure to eat, and even then I've often had issues where it left me depressed and anxious for days afterwards. My friends, who never supplement, do not experience such a crash. At this point, I generally avoid MDMA because the crash is too painful to be worth it.
I've recently had my genes sequenced and found out that I have a slow variant of the TPH2 gene. This gene encodes for the enzyme (tryptophan hydroxylase) which makes serotonin. It's normal that I have more aftereffects after MDMA use, because my brain is probably 2-5x slower at replenishing serotonin. No amount of supplementation will fix this, because tryptophan hydroxylase is the bottleneck.
Brains are more unique than faces. Pretty much every protein involved with monoamines has multiple common genetic polymorphisms. You really shouldn't expect MDMA or any drug to have the exact same effect on everybody.
