I'm guilty and somewhat afraid of going there because of what I see. Most websites and web-apps are the opposite of ergonomics and I sometimes wonder if that isn't the result of the current state of UX field, that focuses on shiny things that you can sell easily instead of building tools that work. The trend I see in UX is that of dumbing-down your software and enforcing one, carefully-drawn user flow, that is pretty but not ergonomic.

I don't want to demonize the entire field - it's just a worry I have, from observation.

In my small amount of experience, reasoned application of Fitt's Law goes a very long way for ui design.

The Humane Interface, by Jef Raskin, goes into the basics, with examples and tests, including synthetic usability measures that can go a long way.

There aren't a lot of good tools or frameworks, unfortunately; you have to do the math yourself.

I think I'm somewhat guilty too, but I did find a cool tool that can help: http://peek.usertesting.com/