If you have a complicated system, the best way to deal with the complexity is to organize it in some fashion. BioFabric provides a way to do that, since it allows the network to be arranged in a linear fashion. Kinda like the advantages of organized adjacency matrix views, but with the intuitive link-hopping model of node-link diagrams. I can't argue that if you put garbage data in, you get garbage out. But, over time, very large but high-quality biological networks will emerge.