Because that implies man is free to make up their own meaning.

No natural law, no nothing -> pure chaos

Put it another way, indifferent universe strongly points to us being a complete accident, our qualia so cherished by us just an absurd joke.

So meaning being null means there is no ultimate answer not even 42.

I still don't see why meaning is null in the case that the universe isn't a conscious agent. Meanings are aspects of us, not of the Universal Consciousness or whatever.