Seriously doubt it. Backwards-incompatible changes (mostly, deprecating some old kludges) had happened many times and I don't think there were any severe migrations.
I'm really not sure cons of User-Agent cleanup (or complete deprecation) outweigh the pros. At the very least I think it's not obvious and is debatable.
Also, some privacy improvements by having less data for browser fingerprinting.
Also, if we'd consider dropping User-Agent header altogether, less ways to detect an UA, so a bit harder to show "sorry, your browser in unsupported, this site is IE^H^H Chrome-only"
Obviously, just UA header isn't even remotely sufficient for any of those reasons, but would be a good start.