There was a moderate amount of speculation in mid-century SF on the possible psychological effects of space travel, the most extreme being "the Great Pain of Space" that figured in an early Cordwainer Smith story: https://en.wikipedia.org/wiki/Scanners_Live_in_Vain
When it turned out nothing quite so dramatic happened to the first space travelers, the idea was dropped, but it's certainly worth considering that less dramatic effects might yet have practical import in the future of human space travel.
When it turned out nothing quite so dramatic happened to the first space travelers, the idea was dropped, but it's certainly worth considering that less dramatic effects might yet have practical import in the future of human space travel.