For GUI apps, I've found Atom Shell (https://github.com/atom/atom-shell) quite convenient as a HTML app wrapper. You can embed Angular.js and Bootstrap to create a working prototype application very quickly. Node.js modules can be require()'d straight into Angular controllers or services.
Looking at the features list, I see, "Complete support for Node.js APIs and all its third party modules."
Does this mean the JS code on your HTML pages has no sandbox between itself and the OS?
Also, how does this compare to QtWebKit [1][2]? I like the idea of blending HTML with native GUI components in a desktop app, or even having a "lite" web only version, become a "full" version when run on the desktop and share as much code as possible.
