I think that it's generally a good assumption, anywhere in business (and most places in life), that whoever you're talking to is self-interested. Not evil, not even necessarily selfish, but it's a good bet that their world revolves around them.
And once you've got this principle ingrained in your mind, navigating the big scary world of business, or VC, or Google, or health insurance, or any other industry becomes much easier. Because you start to look for what people's incentives are, and don't ask them to do things that are against their own incentives. People are much more inclined to cooperate with you when it doesn't hurt their own interests.
People who actually "disrupt" industries, rather than just talk about it, do so by finding loopholes in other folks' incentive structures. They figure out other ways of doing things that incentivize everybody involved to cooperate with them, and that's how they revolutionize things.
The parent talked about fighting evil but the vast majority of people who work in industries like health aren'e evil - they're merely acting in their own self-interest within a system/industry that has evolved, over time, to exploit the vulnerable.
And once you've got this principle ingrained in your mind, navigating the big scary world of business, or VC, or Google, or health insurance, or any other industry becomes much easier. Because you start to look for what people's incentives are, and don't ask them to do things that are against their own incentives. People are much more inclined to cooperate with you when it doesn't hurt their own interests.
People who actually "disrupt" industries, rather than just talk about it, do so by finding loopholes in other folks' incentive structures. They figure out other ways of doing things that incentivize everybody involved to cooperate with them, and that's how they revolutionize things.