>Something to consider is that your brain is already messed with, so the use of drugs might be needed to un-mess it
Absolutely. I came to this conclusion after a few months of therapy and reading several books about ADHD (Driven to Distraction was the first of a rather deep rabbit hole). I was terrified that I'd lose that creative spark I always held unique, because that's what previous psychiatric medicine had done to me.
Bupropion (Wellbutrin) isn't just a dopamine reuptake inhibitor: it's also a norepinephrine reuptake inhibitor and a nicotinic acetylcholine receptor antagonist (which is why it's also prescribed for smoking cessation). It didn't work with me. I was calmer, less hyperactive: but I had a flat affect. I could concentrate on busywork, but I couldn't think. It also wasn't prescribed for ADHD: it was the second attempt to treat a (non-existent) bipolar disorder when I was 15. I'm pretty sure (at this point) my neurochemistry is such that my reuptake rate is fine, but my release/synthesis rate is much too low. Which is why a reuptake inhibitor seemed to only work part way.
The first tried, however was Depakote. In extreme cases it's prescribed to stabilize mood and impulse control with ADHD. It's usually prescribed to quell manic episodes and control seizures. I only dully remember my time on it. I do remember being in a constant fog, a miasma - while I couldn't really think straight beforehand, I could barely think /at all/ on that medication. I was on 900mg/day. Given my bodyweight at the time, my plasma concentrations were probably well above the typical controlled therapy concentrations of 100mg/L. It was probably closer to 200mg/L, which explains the stupor and slight tremors I had.
Given its pharmacology, I can't see how it is, in good conscience, prescribed to those with ADHD unless a manic skewed bipolar disorder is also present.
But the story of why they were absolutely convinced I was manic/bipolar is another thing entirely.
Absolutely. I came to this conclusion after a few months of therapy and reading several books about ADHD (Driven to Distraction was the first of a rather deep rabbit hole). I was terrified that I'd lose that creative spark I always held unique, because that's what previous psychiatric medicine had done to me.
Bupropion (Wellbutrin) isn't just a dopamine reuptake inhibitor: it's also a norepinephrine reuptake inhibitor and a nicotinic acetylcholine receptor antagonist (which is why it's also prescribed for smoking cessation). It didn't work with me. I was calmer, less hyperactive: but I had a flat affect. I could concentrate on busywork, but I couldn't think. It also wasn't prescribed for ADHD: it was the second attempt to treat a (non-existent) bipolar disorder when I was 15. I'm pretty sure (at this point) my neurochemistry is such that my reuptake rate is fine, but my release/synthesis rate is much too low. Which is why a reuptake inhibitor seemed to only work part way.
The first tried, however was Depakote. In extreme cases it's prescribed to stabilize mood and impulse control with ADHD. It's usually prescribed to quell manic episodes and control seizures. I only dully remember my time on it. I do remember being in a constant fog, a miasma - while I couldn't really think straight beforehand, I could barely think /at all/ on that medication. I was on 900mg/day. Given my bodyweight at the time, my plasma concentrations were probably well above the typical controlled therapy concentrations of 100mg/L. It was probably closer to 200mg/L, which explains the stupor and slight tremors I had.
Given its pharmacology, I can't see how it is, in good conscience, prescribed to those with ADHD unless a manic skewed bipolar disorder is also present.
But the story of why they were absolutely convinced I was manic/bipolar is another thing entirely.