Berkeley Brethed ran several Bloom County strips which featured the need for more space too, such as: http://www.thecomicstrips.com/store/add.php?iid=82665

Someone should introduce the man to the internets capabilities. Bill Waterson can have all the space he needs.

I don't presume to speak for Bill Waterson or anyone else (and I don't mean this to be specifically about comics), but having all the space you need is, creatively, usually worse than having not enough space.

There's a sweet spot in the middle where you have enough freedom to realize the gist of a vision, but also a number of unwavering hard constraints to rein you back in.