It takes under 5 seconds for me to compile my project of about 5000 lines. So it's not really a problem for me yet, though I agree it would be if the waitingtime where to become any longer. Besides that, I've also been really enjoying developing in Typescript!
Same here for a project three times this size. Still I find it extremely slow compared to CoffeeScript I was using before. I'm used to saving the file and instantly refreshing the browser/rebooting node.js.