When we applied to YC in 2011, we originally focused on professional women as that is where we saw the biggest need for our content, although 90% of our content was not gender-specific. Very quickly we watched our demographic grow to be 30+% men, and we made the decision to broaden our focus, while continuing to focus on our core: careers. One reason we made that decision is because one of the things we originally wanted to combat was women not feeling welcome in the workplace, so the idea of men not feeling welcome on The Muse (since they were actively using it "in secret" as they said) didn't feel in line with our principles.
More info on that change here: http://www.themuse.com/advice/join-our-new-journey-updates-f...