I understand that you must have invested a lot of your time and energy into this idea, so it may be difficult to accept criticism of its base concept. However by posting about it on a public discussion board you are implicitly inviting others to discuss and critique it, so I don't really see how that can be considered impolite.

Saying flatly "this could never work" is impolite, arrogant, and possibly wrong. "I don't see how this could ever work" suffers from none of these failings.

It could never work (to make animal research obsolete) because there is no human substitute for these: http://www.understandinganimalresearch.org.uk/how/areas-of-r...

And unless it becomes ethically acceptable to genetically modify human embyros for testing rather than mouse embyros, then this is not going to change.

This isn't arrogance or impoliteness, it's just how it is.

Even if animal testing is not made obsolete but is reduced by a large factor, that's huge progress.