I've always been under the impression that bacteria pay a heavy evolutionary tax for their resistance. So what would happen if you then took a sample from the 1000x section of jelly and then another sample of your initial bacteria and put them on opposite sides of nutrient jelly slab. Would the new bacteria be completely overwhelmed?
Would infecting someone with a non resistant strain, letting it sit for a while and then hitting them with antibiotics knock the infection low enough that your immune system could wipe up the rest?
The problem is in situations where you want to use antibiotics, time is not on your side. There has been some work done on this idea, though I cannot recall the specifics.
Its difficult to say if they've reached the end of their 'maximum optimization limit' or a local maximum.
The beauty of evolution is not to be stopped by limits, but to run near infinite instances of optimization algorithms over infinite time scales to over come the limits that exist.
Would infecting someone with a non resistant strain, letting it sit for a while and then hitting them with antibiotics knock the infection low enough that your immune system could wipe up the rest?