I check it with this RegEx to make sure it's in the right format of [string]@[string].[string] to make sure that user at least tries to enter an email address, but beyond that sending and email and getting a response is the only way.
It's mere ^.+@.+\..+ (in both POSIX extended and PCRE dialects) that properly represents the latter.
And even such regexp filters out many technically-valid but obscure cases of RFC-compliant email addresses (for example ai, io, kh and ws TLDs have MX records, and supposedly hostmaster@io should be a valid email address).
I check it with this RegEx to make sure it's in the right format of [string]@[string].[string] to make sure that user at least tries to enter an email address, but beyond that sending and email and getting a response is the only way.