I also think that there's a really huge opportunity here for Big Data to make a Big Impact (excuse me for being cliche). See http://beluga.grooveshark.com for a good example. Imagine the possibilities of linking music consumption data with demographics/sales/tours/etc data to optimize A&R, tour routing, merchandise design, etc. AFAIK there aren't really any strong players in this space, and it presents a fantastic opportunity for someone to make a ton of money.
Incidentally, I'd imagine the same technology, methodologies, and infrastructure used for planning and optimizing shipping routes (first by UPS/FedEx, now Amazon) would be very applicable in this arena.