If you want to take on a non-strawman version of the argument, check out benhammer's links below.
That said, I do often feel that at the literal edges of our universe (in all the senses of that term), our uncertainties simply dominate everything and all of our guesses about the true nature of reality are dominated by that uncertainty. Something (or, depending, multiple somethings) must be true for some value of true, but I'm skeptical if we can discover it. If it popped up and simply flat-out told us what the truth was somehow (the Great Simulator writing the message in the stars [1]), we probably couldn't confirm it.
That said, I do often feel that at the literal edges of our universe (in all the senses of that term), our uncertainties simply dominate everything and all of our guesses about the true nature of reality are dominated by that uncertainty. Something (or, depending, multiple somethings) must be true for some value of true, but I'm skeptical if we can discover it. If it popped up and simply flat-out told us what the truth was somehow (the Great Simulator writing the message in the stars [1]), we probably couldn't confirm it.
[1]: http://lesswrong.com/lw/qk/that_alien_message/