My 2012 rMBP seems to freeze for 5-10 seconds occasionally. dmesg has logs of the graphics driver complaining about a possible hang. We're definitely on the bleeding edge here :(
My 2012 rMBP just started randomly locking up, forcing me to do a hard reboot. It's weird because sometimes I can move the cursor around, but nothing else will work.
How long does it hang? I assume permanently? On mine the caps lock key light doesn't respond to press/unpress (my standard test of system liveness), and then it comes back to life about 5-10 seconds later.
Flash was one of the major contributors to the issue. Even then, after a few days of uptime, video doesn't play properly and browsers will beachball constantly. The solution is to party like it's Windows in 1999 -- reboot.