I could think of a few situations where this is useful. For example, it would be ridiculously easy to write a "publish to my GAE weblog" command for any text editor that can talk to Python.
But would that be the right architecture? I think it would be better to POST some more abstract XML data to GAE-side code, which is then closely tied to the data structures. That way I can test and evlve two parts of the big app independently.