As a counter example, I once had a hard time getting pygame running on OS X. I don't remember exactly what the issue was, it may have had something to do with multiple versions of python installed on my machine, but it was enough of a pain that after a couple of hours trying to figure it out I decided I didn't care enough about checking out pygame to work it out. This might have been the kind of thing that someone more experienced in python would have known how to solve immediately, but for me at the time it was too much.

On the other hand, on other machines it was a breeze to set up.