Hacker Newsnew | past | comments | ask | show | jobs | submitlogin

Can you say more about retatrutide for IBS? My IBS is debilitating to the point where I usually refuse to eat food on week-long work trips, because the unplanned emergency toilet trips wreak havoc with my schedule and ability to sit in meetings all day. I'd never heard there was a solution to it.


Sure, and I totally get your issues. I was a damned wedding photographer and I'd only eat towards the very end of the night, and still had a few iffy days.

As I stated, I originally tried semaglutide with no luck. I didn't try tirzepatide. I've been taking a very low dose of retatrutide - about .5mg twice a week. It seemed to be waning in effectiveness a bit so I upped the dose to 2mg/week for now. It's a night and day difference. Most days I go to the bathroom maybe two times, as opposed to the maybe 5-10 times I would need to unmedicated.

To be clear, this isn't an approved use of the medications (and retatrutide isn't approved at all yet, though it pretty clearly will be). However, they slow down gut motility - and as a bonus for your refusing to eat during week-long work trips, they'd probably at least help with that too, in terms of hunger.




Consider applying for YC's Winter 2026 batch! Applications are open till Nov 10

Guidelines | FAQ | Lists | API | Security | Legal | Apply to YC | Contact

Search: