1. Use global fixed 16bit 44.1kHz stereo, and raw uncompressed lossless codec (avoids gpu/hardware-codec and sound-card specific quirks)

2. Don't try to sync your audio to the gpu 24fps+ animations ( https://en.wikipedia.org/wiki/Globally_asynchronous_locally_... ). I'd just try to cheat your display by 10Hz polling a non-blocking fifo stream copy. ymmv

3. Try statically allocated fifo* buffers in wasm, and software mixers to a single output stream for local chunk playback ( https://en.wikipedia.org/wiki/Clock_domain_crossing )

* recall fixed rate producer/consumers should lock relative phase when the garbage collector decides to ruin your day, things like software FIR filters are also fine, and a single-thread output pre-mixed stream will eventually buffer though whatever abstraction the local users have setup (i.e. while the GC does its thing... playback sounds continuous.)

Inside a VM we are unfortunately at the mercy of the garbage collector, and any assumptions JIT compiled languages make. Yet wasm should be able to push io transfers fast enough for software mixers on modern cpus.

Best of luck =3