Is this the case with an active social life as well? I don't find that most of my socializing and interaction comes from my co-workers (who are significantly out of my age range).
I've never worked from home, but I'd really like to. I like to think as long as I still socialized after work (happy hour type stuff, kickball league, etc.) I wouldn't feel the isolation and depression.
You underestimate how much of your social interaction comes from your coworkers. I've been remote for 3 years now, and my social network has atrophied to nothing, with the exception of some superficial interactions on facebook with people I used to see every day. To be fair, I have been traveling pretty consistently since I started this arrangement, and nobody wants to be friends with a transient. I mostly cope by working out several hours per day, but I'm at the end of my rope and all I really want is to settle down (as soon as I find a mid-sized city with year-round perfect weather, cheap cost of living, and a thriving community of creative technical professionals ;)
edit: That being said, I'm not sure I would be able to return to regular office work and all the social posturing that comes along with it.
I certainly interact with my co-workers at work and talk about the normal stuff (sports, news, politics, etc.), but outside of work I see my co-workers 0% of the time, unless I coincidentally run into them.
My outside of work socializing is simply people I've either met on my own or through the 2-3 people I knew in the city befor I moved here 2 years ago.
I would recommend Honolulu for your relocation, but cost of living is a little steep (but manageable...and worth it) and our tech community is definitely in the development stage (though it is existent and fairly active).
EDIT: I want to clarify that I probably do underestimate the benefit of my work interactions. The reason I go out and socialize so much is that I find myself feeling isolated and lonely on nights/weekends where I choose to stay in.
I've never worked from home, but I'd really like to. I like to think as long as I still socialized after work (happy hour type stuff, kickball league, etc.) I wouldn't feel the isolation and depression.