The Nspire CAS is really more of a tool for students. I'd call the point-and-click interface clunky and intuitive--it's not hard to figure out how to do things, it's just going to take you a while to get there. :) I'd imagine if you have software you've written for the TI-86 and are inclined to do integrals and differentials on paper until you get stuck, it's probably not the right tool for you. :)
I agree with you there about the student comment! I do find it poorly integrated though, for example:
To do a linreg on some data and project that past the extents of the dataset requires...
NSpire: create document, create spreadsheet, enter data, create stats plot, analyse->regression->linreg, create graph, plot stat func, set zoom constraints, whack X value in, read Y.
That's just shit, student or not.
TI-86: {1,2,3,4}->xStat, {3,6,8,10}->yStat, catalog->LinReg, Graph, zoom, enter X, done.
Probably right about it not being the right tool.
Anyone want to buy an NSpire CAS? £30 including delivery to the UK :)