Mission drift can sometimes go in a positive direction. The Howard Hughes Medical Institute, for example, functioned primarily as a tax evasion vehicle while Hughes was alive. After his death, the HHMI was in deep trouble with the IRS and sitting on an endowment of ~$5 billion. So it appointed former NIH director Donald Fredrickson to turn it into an actual research funding organization and mend relations with the tax authorities and research community.

https://www.latimes.com/archives/la-xpm-1986-08-11-fi-2620-s...