I use these settings on all my browsers to prevent DoH and make sure traffic goes through my Pi (I run unbound directly on the Pi though, not Pi-Hole: in my experience unbound is a bit harder to set up initially but it's also more powerful than Pi-Hole... For example unbound accepts wildcards in blocklists).
It's not incompatible with also blocking, at the firewall level, all known DoH servers of course.
Nor is it incompatible with forcing your router to also use your Pi as a DNS.
https://support.mozilla.org/en-US/kb/dns-over-https
I use these settings on all my browsers to prevent DoH and make sure traffic goes through my Pi (I run unbound directly on the Pi though, not Pi-Hole: in my experience unbound is a bit harder to set up initially but it's also more powerful than Pi-Hole... For example unbound accepts wildcards in blocklists).
It's not incompatible with also blocking, at the firewall level, all known DoH servers of course.
Nor is it incompatible with forcing your router to also use your Pi as a DNS.