I chose Django + htmx and a small amount of Alpine.js for a full-stack software project that is currently being launched. I had zero professional experience with Django (or Python really) before starting. I was able to develop the entire application on my own, in my spare time, and had time left over to also handle infrastructure and devops myself.
I prefer Python and it's web frameworks over Typescript/React because there is a lot more stability and lot less "framework-of-the-week"-itis to contend with. It's much easier to reason about Django code than any React project I've worked on professionally. IMO when you don't have a firehose of money aimed at you, then Python is the way to go
Yes, you can do the whole web app (or web site if you will) like that without any complicated dependencies. This will be great if you touch the project only now and again e.g. the typical side project that you want to still work in the year 2030 without major changes.
Yet the approach also scales up to enterprise grade project, leveraging DRF, Django-cotton and so on (and htmx).
I prefer Python and it's web frameworks over Typescript/React because there is a lot more stability and lot less "framework-of-the-week"-itis to contend with. It's much easier to reason about Django code than any React project I've worked on professionally. IMO when you don't have a firehose of money aimed at you, then Python is the way to go