I've recently been studying typography and it's been really heartbreaking to realize that what differentiates a good and a bad typeface onscreen is how it well it renders. Plenty of great typefaces are just unusable. Most fonts distort wildly as you step up/down in pixel size. I didn't start in print design, but man is web design primitive in comparison!
I have to admit that rage was starting to burn inside of me until I read your last sentence– that's one of the reasons why I take so few jobs for the web these days. I always thought that web technologies would far surpass what we could do in print (which, as a lead type junkie, sounded pretty amazing) and then I grew up, started dealing with W3C &c;– now here we are, only in the last two years or so getting a reliable (and compliant) way of using more than just Times, Georgia, Helvetica, Arial, &c... It's slow, slow progress but it's great to see that while those issues are hashing themselves out that the pixel problem is practically resolved. (Though I should note that pixels or not, setting a spread to be displayed digitally was never that much of a problem if it didn't have to be displayed in the browser. Sure, some fonts have shitty hinting but the ball is at least in your court.)