I have Cablevision and they technically allow you to opt out. But even after opting out, I still get that damned useless ad-infested search page sometimes, seemingly at random. I'm not sure if it's because of their incompetence of malicious intent.
If you're using Comcast Business, I've yet to find a way to do this. Comcast Support (email, phone, live chat) also have no idea. If anyone knows how to do it, please let me know.
That is my experience with comcast dns too. Although, I have had some issues with google dns too on a rare occasion where I had to change back to something else (comcast or opendns) for a short while until google dns worked again. They never hijacked anything, but it just stopped working for a brief period.
Also because Comcast DNS sucks horribly and times out with upsetting regularity.