Check eg https://simonwillison.net/2024/Dec/19/one-shot-python-tools/

  #!uv run
  # /// script
  # requires-python = ">=3.10"
  # dependencies = [
  #     "click>8",
  #     "rich",
  # ]
  # ///

and that's it

Cool. I wasn't sure it would skip the first comment line.