This is very relevant to me. As someone who's doing the SV startup thing full time, spending all of my waking hours on learning / doing stuff / meeting people, am I seriously not going to regret taking a dump on my 20s in 10 or 20 years? Am I not going to regret missing out on youth, girls, fun and so on, if I spend all of these years working on achieving my dreams?
Make a commitment to balance. I partied very hard in my teens and 20s and regret nothing. Some of my friends worked on professional degrees and are now late 20s early 30s trying to recover what they can of their youth. Another set of friends still pour their energy into partying but worry about money. For energetic people, the most important thing is balance. Work effectively, party hard, don't listen to too many people, be brave and don't make their concerns yours.