There is clearly a difference in the uptake of fructose and glucose as you can see here, no insulin is required to uptake fructose. https://phdmuscle.com/fructose-metabolism/
If there is a difference in fructose and high fructose corn syrup it would likely be the fact that it is corn based. Corn has been selected to be farmed with high glycophosate (round up ready), which metabolically different from other corns and produces some proteins not found in non GM corn. https://enveurope.springeropen.com/articles/10.1186/s12302-0...
Its true, check the link and look at the metabolic pathway. insulin is a response to glycogen from the fructose 6 phosphate formed during glucose metabolism. since fructose converts to fructose 1 phosphate form no glycogen is released and so no insulin is required to uptake fructose.
Anyway, apparently HFCS contains about 50% glucose so it would require insulin, but less than pure glucose.
Fructose doesn't need insulin to be converted to glucose in the liver, but I don't think this is what you are thinking at all. Fructose isn't used by the body directly, it almost always has to be first converted to glucose first. Glucose does require insulin to be pulled into cells throughout the body. So fructose does require insulin to be used by the body for energy or to be stored into fat.
When you say insulin isn't needed for fructose it's a fundamental misunderstanding on a few different things.
My layman understanding is that insulin is used to absorb blood glucose into muscle and fat cells, while fructose is processed by the liver into other things (which may include glucose), but that initial processing doesn't require insulin.
If there is a difference in fructose and high fructose corn syrup it would likely be the fact that it is corn based. Corn has been selected to be farmed with high glycophosate (round up ready), which metabolically different from other corns and produces some proteins not found in non GM corn. https://enveurope.springeropen.com/articles/10.1186/s12302-0...