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Do you recall which position?



> Glymphatic transport is most efficient in the right lateral sleeping position

https://pmc.ncbi.nlm.nih.gov/articles/PMC7698404/ Section 3.4.3


Yes that’s the position. Good to see it verified in the study. Having a partner and sleeping in the same bed can lead to alterations from the optimal sleeping position, especially sleeping on the back is not good. Sleeping on the back is also one of the main causes of snoring, which often occurs in people which have a big belly and can’t really sleep lateralish anymore.

Sleep quality is important too and one big factor is not to go to sleep with a full stomach. Sleep quality will suffer because of the active digestion which probably will not let the glymphatic transport do it’s job properly.

Also good to know that “…low doses of alcohol (0.5 g/kg) increased glymphatic clearance…”.


Is increased glymphatic clearance good or bad?


good


That's great that there's a way to passively optimize that process every day. But it's also bad news considering it's contrary to what you need if you have GERD.

https://pmc.ncbi.nlm.nih.gov/articles/PMC10643078/

> A limited number of studies have demonstrated that sleeping in the left lateral decubitus (LLD) decreases nocturnal reflux in patients with gastroesophageal reflux disease (GERD) compared to right lateral decubitus (RLD) and supine.


> Glymphatic transport is most efficient in the right lateral sleeping position, with more CSF clearance occurring compared to supine and prone [6]

Reference [6] is a study on rats! The authors suggest further investigation in humans.

Even though I would bet on this still holding for humans.




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