Blizzard is pretty strict with the anti-cheating checks, which may be part of this. It's also very annoying that you can't run Diablo 3 on OS X if you have Filevault enabled, for example.
That doesn't sound right, I've had Filevault on the entire time I've been playing Diablo 3... unless that's come in on the latest update cause I haven't played it in a couple weeks.
"This error is caused when FileVault options are enabled, or if a volume is formatted as case-sensitive. These options are not supported for installation."
"If FileVault is enabled, then Diablo III will not install."
I've had Diablo 3 running with File Vault, until a couple of patches later when it just refused to install the newest patch. Now, I can't even install it anymore. I'm unsure if it is a connection problem or related to File Vault. (Trying to install it on an external unencrypted Firewire drive failed too.)