Nah. Not in this day and age. Most of that software can be recompiled - hopefully no one is writing stuff in assembly, at least not to the point where it can't easily be ported. With many-core CPUs cheap and common, everything is fast. Hardware drivers matter less in the 2020s - there is far less diversity of hardware than there was in the 1990s. x86 "know-how" is vendor lock-in, not a benefit.
GPUs are really the only thing requiring their own hardware drivers that's commonly installed. Everything else common and meaningful to the masses is pretty much USB, an old-school serial port, a network interface, or a block device. Bus/interconnect drivers like NVMe, SATA and all that are very standardized and your x86 know-how doesn't buy you any advantage.
Certainly there may be some issues with the trash heap that is ACPI/UEFI; and DTB can go ahead and steamroll that dumpster fire along with the rest of the x86 cruft - there was an x86 world before ACPI after all.
