They've been in use for years now in that war. The Shahed drone, for example, was used by Russia. About two years ago Ukraine was using autonomous drones to down Shahed drones.
AI targeting came out in the Gulf war, friend. 35 years ago, Tomahawks could use rudimentary AI to match preprogrammed terrain profile and target imagery to get more precise targeting.
The Shahed drone can't use it's INS system to communicate with a ground operator or reprogram itself. As the other comment says, it's basically a glorified cruise missile that has the autonomy of a Roomba. Disabling a Shahed with another drone may have happened, but it's certainly not the primary threat to the Shahed when compared to CIWS or SAMs.
AI targeting was debuted in the Patriot missile system, which does technically field the required elements of a hands-off kill chain. But TERCOM is not AI nor was it debuted in the 90s with the TLAM. The original BLOCK-I variants of the Tomohawk (and many versions released afterwards) were no more autonomous than the Shahed-136.
Depending on when the tech is available, preventing GPS jamming of drones is probably much more urgent in Ukraine.