+1 for Pyxel, recently used it for a couple of hours to create a tiny project [1] and loved how intuitive it was.

[1] https://github.com/abhishekbasu/minesweeper

This is very cool!

As an aside, I find it frustrating how different Python packaged want to be installed in different ways. Pip this, conda that, and now… pipx?

I worry about how all these systems will interact and conflict.

In by far most cases you can still find the package on pypi.org and install it through pip.

pipx is not a different packaging system. It uses pip.

Conda is mostly used by data science people for some reason.

Not sure but i think conda can actually build/ship stuff like c/c++ modules for speed up for critical python code. Example: https://www.pymc.io/ i used for mcmc stuff. Installing on windows without conda is practically impossible. On linux (or wsl for that matter) if you have gcc or other compilers installed it works via pip with no issue.