https://grail.com/ seems like the path we're on for that sort of screening (blood borne cancer biomarker surveillance)? AP-1 tweaks + mRNA and immunotherapy protocols for detected cancer + continued cancer screening developments might be a material longevity improvement. Typically, you're trying to die before any cancer gets you long term, so the need is to continually improve cancer detection and treatment.

https://www.cancer.gov/about-cancer/treatment/types/biomarke...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074993/