You can rent a car with a debit cards in many cases. Avis has a page [1], but it's lacking specifics, so you probably need to call the desired rental location to verify. Enterprise seems to say they accept debit cards (with some restrictions/deposit requirements).

Doesn't seem like a can't, although it might be in some locations.

[1] https://www.avis.com/en/help/usa-faqs/debit-card-policy