There is no music or NPC dialogue. I spent a few hours scouring for all manner of fixes before giving up. So many "This is what fixed it for me:" that didn't work on my machine.
There were also some rendering issues, but I could let that slide given my GPU is ~10 years old.
I haven't tried that game, but I know for a fact that Fallout 4 works quite well, and it -- like Skyrim -- has a gold status on protondb.