It is being used off label all over the place for heart conditions. That’s why i take it. The on label use is actually pretty annoying for the first few months.
No. You get hard easier and it takes longer to go down, but without (mental) stimulation, there is no erection. (for the vast majority of people taking sane dosages)
Not OP, but their statement read as if that effect wears off after the body develops tolerance to the medication. So, yes they did for a while (it was annoying) but no they don't now (for a few months)
There is NO tolerance development, on the contrary, increasing vascular health by long term PDE5 treatment and increasing psychological confidence over time make the treatment more effective with time.
You're taking about slightly different things - you about ED, the other person about "boner all day". They are not the same thing.
Slightly off topic, but this is why I don't really trust these "no tolerance" claims. That claim is usually very specific, while people's understanding of "tolerance" is often quite a bit wider.
I take 3 medications which each make "no tolerance" claims based on scientific studies. But my subjective experience is that all of them do build tolerance in some way - the subjective effect does wear off with time and taking a break does reduce the tolerance. One possible cause is mistaking the intended effect (ED) with side-effects (boner all day).
The first time I took sildenafil I had a bad headache and nausea, the next couple of times I didn't suffer from nausea and the headache wasn't as severe. I don't suffer from any side effects now other than my nose getting a bit stuffy every now and then, so in that sense I developed a tolerance to the medication's side effects. The boner effects still work just as reliably as day one, no tolerance development for me there.
you are lucky, in addition to the migraines and stuffy nose, sildenafil altered my vision making everything looked blue tinted. I tried a couple other drugs in that class but the migraines never went away.
Long term PDE 5 treatment lowers estrogen and increases testosterone. As a consequence of that, and its cardiovasvular effects, it makes it easier for the body to turn fat into energy by fat-browning, to grow muscles and to lose fat.
I don't know how people imagine viagra working - it's not like you take a pill, you continue browsing the internet, reading news, and suddenly, a boner lifts your desk.
Was news to me to read in a sibling that it also requires mental stimulation. I thought it was purely a physical inducement by the drug, as many drugs for other purposes induce a physical response without requiring mental effort.
>it's not like you take a pill, you continue browsing the internet, reading news, and suddenly, a boner lifts your desk.
Aside from the lifting the desk part, that's exactly how I imagine it working - and how it should work. You mean it also requires special sexual arousal? Well, even that it shouldn't be that difficult.
That’s not how it works at all. As someone with recent onset of ED taking viagra regularly, it’s been fantastic but it just makes me function like I should.
It takes about an hour to take effect (usually less for me) and lasts a little over 4 hours with some lingering effects for several hours later, with diminishing effects towards the 4 and above hours.
If I’m sexually stimulated during that time physically and or mentally, everything works like it should (erection). If during that time even when I would normally see peak effects around the 50 min to 90 min mark I’m driving or doing taxes or whatever non-sexually stimulating activity one might do, no erection at all.
> Viagra should make you "pop" regardless of what activity you're doing.
No it doesn't. It simply makes the effect of sexual stimulation more effective. If you body is not trying to engorge the penis it has little to no effect on that part of you.
Tadalafil works well for getting more out of your workouts too (I take that). Gives you an overall feeling of well-being too (better than any cup of joe), I no-bullshit begin my day with it.
I know a former executive of the company that was developing this drug for cardiovascular problems. He told me that they sold it because it had this "side-effect" that they couldn't get rid of. ;-)
Marketing is the key to business success.
(Talking to you, tech people)
Marketing as I was taught in a fortune 500 is the end to end process of delivering a product/service to the target customer.
Good product is the table stakes. (entry requirement)
Everything else is in the marketing plan.
We don't know how many medications actually function. We put them inside of increasingly complex animals and study the results to see what they do (and hope they don't die). Botox was intended to treat muscle spasms. Powerful anti-depressants are regularly prescribed for pain from nerve damage in people with no mental health issues. And MDMA isn't prescribed for anything because the powers that be prematurely decided to ban it based on completely fabricated claims, which I assume is part of a massive hundred-year conspiracy to make sure people... keep dying from alcohol? Not totally sure about that last one, but it's hard to deny the facts.
I work on health equity things in healthcare occasionally. I think this is so dumb. MDMA rejected by panel recently for evaluating rescheduling for use in PTSD.
“ Panelists pointed to flawed studies that could have skewed the results, missing follow-up data on patient outcomes and a lack of diversity among participants. The vast majority of patients were white, with only five Black patients receiving MDMA, raising questions about the generalizability of the results.
“The fact that this study has so many white participants is problematic because I don’t want something to roll out that only helps this one group,” said Elizabeth Joniak-Grant, the group’s patient representative. “
this is the case with almost all drugs. for example almost every antidepressants was the result of a weight loss or something like that.
drug research is worse than training an LLM. you feed it to random people and then compare effects with initial conditions and of something looks good you try with more control.
