I only know what I know from a podcast but I think that has a lot more to do with your liver and its enzyme profile than your brain. I know someone who took 90mg a day (I assume it’s higher now) just as a clinical dose - they’ve probably never experienced a recreational dose because it would probably be an obscene-looking amount. THC is like this, too, when ingested. Some people can eat 100mg and barely get a buzz but that dose would knock most people out. Inhalation is a different story - baseline tolerance from person to person doesn’t vary nearly that much (from what I’ve seen) and as far I know the difference is that the liver doesn’t come into play since cannabinoids cross the blood brain barrier on their own.

Huh? Amphetamines are directly absorbed into the brain. That is what Adderall is.

The liver eventually removes them, they aren’t responsible for the effect.

Both of these folks took them in pill form.

Do you mean snorting vs ingesting? Snorting definitely increases uptake yes, but the underlying brain chemistry differences still exist.

Easy to find folks who figured out they were ADHD because they did a line of cocaine and almost fell asleep, for instance.

I was wrong to bring up the blood brain barrier and the liver. My point is that an individual’s enzyme profile* is more relevant to dosing than whether or not they have ADHD, which seemed to me what you were implying here:

> One friend (into recreation drugs) took 40mg

> Another (prescribed) took 80mg

You can take someone undiagnosed with ADHD, give them 80mg and they could possibly not feel a thing. Likewise there are those who are prescribed low doses like 2.5mg.

It’s a pet peeve of mine the myths I’ve seen shared pervasively on SM:

1) getting high from a stimulant doesn’t preclude you from having ADHD. I know this is not what you said but I’ve read comments that literally state if you experience euphoria or other stimulating effects from Adderall, then you couldn’t have ADHD. That’s clearly not how ADHD is diagnosed. Therapeutic dose is all about minimizing those “side effects”

2) that certain people with ADHD cannot experience a stimulant high. That seems extremely dubious to me. Barring a higher dose of amphetamine or more straightforward meth, I’m sure if they can’t get it there then they could from MDA, MDMA, coke, DMT, mescaline, LSD or plain old THC… yes even from a psychedelic it’s a stimulant effect. It’s not the ADHD it’s the personal chemistry

* said enzymes exist in the brain, too, of course, I didn’t know that till I googled more

Edit: typo and format

And you got this.... from a blog post? Or podcast? I forget.

Care to link to any actual studies on this?

Knock yourself out buddy: https://www.hubermanlab.com/episode/adderall-stimulants-and-...

Yeah, that's literally useless. Actually support your claims, or be ignored.