Understand first, then fix. And you understand by measuring the right thing at the right time (scope). Systemwide resource utilization averages are not gonna tell you where your critical thread or database connection is spending their time at - you need to measure (profile) precisely where your task of interest is spending their time.

I've learned a lot from Cary Millsap over the last 2 decades and he recently published a general performance optimization book "How to Make Things Faster" that I can recommend [1]. It's less about tools, more about the method and systematic approach for performance optimization:

[1] https://method-r.com/books/faster/